Cryotec:
Where science
meets
life’s miracles

Welcome to Reprolife, your trusted partner for cutting-edge reproductive solutions. Explore our exclusive Cryotec product line, specifically designed to empower embryologists' work in oocyte and embryo vitrification and warming.

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What is
Cryotec?

Cryotec is an innovative method and product line developed by Dr. Masashige Kuwayama and REPROLIFE Inc. for the vitrification and warming of oocytes and embryos. It features simplified protocols, embryologist-friendly product designs, and focuses on achieving high survival rates in cryopreservation.

Why
Cryotec™?

The Cryotec Method is a simple and safe technique for vitrification and warming that can be applied to the cells of any stage, using a unified protocol that leads to outstanding success rates in oocyte preservation, while consistently delivering exceptional outcomes with embryos.



Some of the advantages of
the Cryotec Method include

NO TIME PRESSURE
DURING THE PROCEDURE

thanks to its low toxicity, each step can be carefully observed and confirmed before proceeding.

MINIMIZED
OSMOTIC CHANGES

this means that oocytes and embryos of all stages can be treated using the same protocol, leading to greater efficiency and convenience.

SAFE SOLUTIONS
WITH ULTRA LOW TOXICITY

Cryotec is a safe and effective method even for lower-grade oocytes and embryos that would be difficult to vitrify using traditional methods.

EFFECTIVE FOR SENSITIVE
OOCYTES/EMBRYOS

Cryotec can be used to safely vitrify and warm oocytes and embryos that are sensitive due to the patient's age, constitution, or medical conditions.

OUTSTANDING
SUCCESS RATES

in oocyte preservation, empowering women through pre-emptive oocyte freezing, including those facing infertility due to cancer treatment

Cryotec is Evolving
with Ready to Use

We have obtained new clinical data based on 1,041 embryos vitrified and warmed using Cryotec Ready to Use kits across 13 clinics* in Japan between September 2022 and April 2024. This data is compared with a previous set of 1,041 embryos vitrified and warmed using another brand at the same facilities.

Pregnancy Rate Results

Pregnancy rates were evaluated based on the presence of gestational sacs.

Comparison of pregnancy rates of other product and RtU at the same facilities

Other Brand
RtU
Average age
35.9
35.7
GS(+)
510
547
Total
1041
1041
Pregnancy rate
48.99%
52.55%
60%
40%
20%
0%
48.99%
Other
brands
52.55%
Cryotec
RtU
Product
*updated August 2024

The facilities achieved a pregnancy rate of 52.55% with Cryotec Ready to Use compared to 48.99% with another brand, representing a 3.56 percentage point increase in pregnancy rates.

Additionally, the facilities were able to save time on the vitrification and warming procedures due to the qualities of Cryotec Ready to Use products, such as pre-dispensed and highly effective solutions. *The facilities that participated in this study are located across various regions in Japan, including Aichi, Tokyo, Iwate, Miyagi, Toyama, Kyoto, Osaka, Yamaguchi, Hokkaido, Kanagawa, and Fukui. These facilities have chosen to remain anonymous.

Dr. Masashige Kuwayama -
Innovator in Assisted Reproductive Technology

Dr. Masashige Kuwayama - Innovator in Assisted Reproductive Technology (ART), has revolutionized cryopreservation in ART.
His advancements in solution composition, device design, and simplified protocols significantly improve success rates for oocytes and embryos. Recognizing the need for safer oocyte cryopreservation, Dr. Kuwayama provides opportunities for women facing age-related infertility and those undergoing cancer treatment. His unwavering dedication drives innovation for high survival rates and stress-free vitrification for embryologists.

Contact

You can inquire about practical training on the Cryotec method, entering into the Challenge 100, free online workshops, and requests for COA (Certificate of Analysis) by filling out the contact form.