Our aim is to support all individuals who desire to have children
and all healthcare professionals involved in this journey.
Infertility is a deeply personal and emotional journey.
At REPROLIFE Inc., we empathize with the challenges on the path to parenthood.
Our unwavering commitment is to provide the finest cryopreservation products for human oocytes and embryos.
Founded in Japan by Dr. Masashige Kuwayama in 2010, our mission is to help
individuals worldwide realize their dreams of becoming parents.
To fulfill this mission, we tirelessly develop advanced technologies in assisted reproductive health.
Our Cryotec product line incorporates cutting-edge vitrification and warming technology,
continuously enhanced through our research.
It is an honor for us to contribute in bringing joy to as many lives as possible,
and we remain dedicated to making our products accessible globally.
“At Reprolife, we believe that every patient deserves the chance to experience the joy and fulfillment that comes with having a family, and we are honored to play a role in making that possible. Together, let's continue to bring hope and happiness to patients and families everywhere.”
Dr. Masashige Kuwayama is a highly regarded embryologist and the founding chairman of Reprolife. He is recognized as a pioneer of human oocyte and embryo vitrification in the world and was named the best embryologist in the US in 2015.
With over 30 years of experience in vitrification research, Dr. Kuwayama began his career as a researcher in Veterinary Science at Japan's National Institute of Animal Industry in 1986. He and his colleagues demonstrated the successful birth of live calves from eggs frozen before fertilization, which ignited his interest in cryopreservation. In 1990, he became a leader of the world's largest bovine IVF center, where 200,000 oocytes were fertilized per year. He succeeded in developing a bovine IVM system and IVC using the co-culture and chemical conditioned media system, a direct transfer method, vitrification of oocytes and blastocysts, and also in producing somatic cloned cattle.
In 1999, Dr. Kuwayama shifted his focus to human reproduction and quickly achieved oocyte vitrification. He developed a clinical vitrification method for human oocytes and embryos in 2000 (The Cryotop method) and established the world's first human egg bank in 2001 to support cancer patients and women who had a preference for later pregnancy.
Since then, Dr. Kuwayama had continued to develop the vitrification method in the pursuit to achieve the highest survival rate, easiest handling, and quickest results. He finally completed this work in 2012, naming it The Cryotec Method.
Today, the Cryotec vitrification method represents a significant advancement in solutions and instrumentation and has been used in over 5 million clinical cases across more than 60 countries. In 2022, he introduced the Cryotec Ready to Use (RtU) product series, which was designed with both patients and embryologists in mind.
Throughout his research, Dr. Kuwayama remains mindful of patients worldwide who are struggling to have children. His motivation is to use cryopreservation technology to help make their dreams of having a child come true.
Achieved successful cryopreservation of bovine in vitro fertilized oocytes using the vitrification method.
Successfully implemented human oocyte cryopreservation using the vitrification method through the minimum
volume cooling (MVC) technique.
Developed a human oocyte vitrification kit.
Established the world's first human egg bank in the USA.
Achieved successful pregnancies and deliveries using cryopreserved oocytes in the United States,
South America, and Europe.
Succeeded in human ovarian tissue vitrification.
Created an HPC-based vitrification solution and the Cryotec Method, which has led to significant improvements in
solutions and instrumentation and has been used in over 1,000,000 clinical cases across 60 countries.
Received the Embryologist of the Year Award in the USA.
Developed the Cryotec Ready to Use series, which represents his latest contribution to the field while also
furthering the work of embryologists worldwide.
“Our vision at REPROLIFE is to share the "joy of weaving life" with everyone and to spread it throughout the world. With this vision in mind, we will strive to bring joy and happiness to everyone involved with REPROLIFE.”
“Our company takes great pride in knowing that our existence serves a purpose and contributes to the birth of new life, which is an invaluable experience. We believe that finding delight in our social responsibility and making it our motivation knows no bounds in terms of possibilities.”
“Our AIRT Research team is dedicated to developing and testing new fertility solutions in pursuit to improve success rates. We strive to innovate in reproductive health, providing hope and support for family building.”
“We will do our utmost to be a source of strength for the embryologists around the world who work with the tiniest lives every day, as well as for the patients around the world they serve."
Our instructor team at ReproLife is dedicated to training our customers in the proper use of Cryotec products for oocyte and embryo vitrification. Their expertise ensures that our customers receive comprehensive guidance, empowering them to maximize the benefits of our products.”
After graduating from postgraduate school in 2010, Yui had been working as an embryologist at a clinic in Tokyo, Japan for seven years. As an embryologist, she has been involved in ART and worked to help many patients to have a baby in the future. She then got a Master of Science in Reproductive Science and Women’s Health from the postgraduate school in the UK in 2017. After returning to Japan, she wanted to use her experience to help embryologists in their efforts to create more lives. She now works as a technical instructor at Reprolife alongside Dr Kuwayama on a variety of freezing methods and shares the Cryotec method with the world as part of the technical assurance team.
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"On every experiment, I use all the expertise that I have to solve the upcoming fertility problems.
On every workshop, I make sure to share all my knowledge, so others can make the best use of our technology.
All the time, I give all my heart to help realize the hopes and dreams of those who want to become parents."
Sofía is a biologist. She started working as an embryologist in 2008. In 2015 she got her PhD in Biomedical Sciences from Universidad de Guadalajara, and moved to Japan to be part of the Reprolife family. Since then she has performed as a senior scientist and official Cryotec trainer giving workshops and lectures worldwide and publishing scientific papers. Sofía wants to give her contribution to the world by creating and spreading the best scientific tools. She loves making friends and learning new cultures, and looks forward to exchanging knowledge with you on the best assisted reproduction techniques.
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"I hope to contribute to the advancement of assisted reproductive technology by applying the knowledge I have gained so far. Although I do not have direct contact with patients, it is fulfilling for me to be able to contribute to the improvement of oocyte and embryo cryopreservation techniques among embryologists through the dissemination of the vitrification method. My greatest satisfaction comes from knowing that more infertility patients who are struggling can find happiness."
Takahito completed his master's degree program at a graduate school in 2017. During his undergraduate and graduate studies, he conducted research on improving the quality and cryopreservation outcomes of bovine embryos, publishing a paper in an international journal. With a desire to apply his knowledge of assisted reproductive technologies for the benefit of others, he joined a clinic in Tokyo as an embryologist. Drawing upon his experience as an embryologist in two infertility treatment facilities, including the pioneering work of Kuwayama in vitrification, he found the current position at REPROLIFE appealing, as it allows him to contribute to the dissemination of vitrification techniques. Takahito joined REPROLIFE and currently works in the technical department, striving every day to promote the adoption of the vitrification method through Cryotec workshops.
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"My greatest joy is to see patients who are undergoing treatment achieve pregnancy and give birth. I strive every day to contribute in any way I can to support embryologists who play a crucial role in ART, and to become a trainer who can help even a single additional patient."
Miyako developed an interest in the profession of embryology due to her own parents' experience with infertility treatments. After graduating from university in 2018, she worked as an embryologist at a clinic in Kanagawa Prefecture for approximately five years. She primarily engaged in ART procedures, providing support for patients' pregnancy and childbirth journeys. Drawing upon the knowledge and experience gained in the field, she aspires to contribute to the essential role of embryologists in the field of assisted reproductive technology. In 2023, Miyako joined REPROLIFE and currently works alongside Professor Kuwayama, dedicating her efforts to promoting the widespread adoption of the vitrification method among embryologists nationwide through workshops.
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"During my time as an embryologist, I always strived to be an embryologist who could empathize with the patients' desire to have a child. Even now, I haven't forgotten that feeling and I aspire to support patients through the work I can do."
During high school, Minori learned about the profession of an embryologist and was deeply impressed by its responsibilities. As a result, she enrolled in a university with a veterinary medicine program. During her university years, Minori primarily studied animal reproduction. After graduating in 2015, she worked as an embryologist for five years. Since joining ReproLife in 2020, her role as a trainer involves imparting accurate knowledge and techniques to embryologists nationwide, with a primary focus on Japan.
